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Updated: Jul 11, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

デオキシトレオシルフォスフォナート核酸化物は,選択的な抗HIV剤として使用されます

Tongfei Wu1, Matheus Froeyen, Veerle Kempeneers

  • 1Laboratories of Medicinal Chemistry and Virology, Rega Institute for Medical Research, Minderbroedersstraat 10, Leuven, Belgium.

Journal of the American Chemical Society
|April 7, 2005
PubMed
まとめ

2つの新しいフォスフォナート核酸化物,PMDTAとPMDTTは,観察された毒性なしで強力な抗HIV活性を示しています. HIV-1逆転写酵素によるDNAへの組み込みは,抗ウイルス剤としての可能性を示唆しています.

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