早期のパンデミックである黄金球菌 (Staphylococcus aureus) が,コミュニティで得られたメチチリン耐性クローンとして再現した
D Ashley Robinson1, Angela M Kearns, Anne Holmes
1Department of Biology and Biochemistry, University of Bath, Bath, UK.
Lancet (London, England)
|April 7, 2005
まとめ
有名なStaphylococcus aureusファグ型80/81のクローンは,一旦排除され,再び浮上しています. 子孫はメチシリン耐性を示し,コミュニティ感染と関連しています.
科学分野:
- 微生物学 微生物学とは
- 感染症 感染症は感染症です.
- 遺伝学 遺伝学とは
背景:
- ペニシリンの耐性のある黄金球菌ファグ型80/81のクローンは,1950年代に世界的な感染を大きく引き起こした.
- このクローンは,ペニシリネーゼ耐性ベータラクトーム抗生物質の導入により,1960年代までにほとんど根絶されました.
研究 の 目的:
- 80/81年初頭の単離物におけるパントン=ヴァレンタイン・レウコシジン遺伝子の存在を調査する.
- 80/81系統の進化軌跡と現在の流行を決定する.
主な方法:
- マルチロカス配列解析は,Staphylococcus aureus.の遺伝子系統を追跡するために使用されました.
- 単離物は,Panton-Valentine leucocidinを含む特定の毒性遺伝子の存在を分析した.
主要な成果:
- 80/81クローンの子孫はメチシリン耐性を獲得した.
- 80/81の血統は,コミュニティ感染の重要な原因として再び浮上しています.
- この再出現するクローンは,パンデミックで病院で獲得されたMRSA株と密接に関連した独特の系統を表しています.
結論:
- 80/81 黄金球菌のクローンは進化し,メチシリン耐性で再現しています.
- この再出現は,コミュニティ感染の新たな脅威をもたらしています.
- このクローンの遺伝的適応を理解することは,公衆衛生の介入にとって極めて重要です.
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