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Updated: Jun 23, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Ubiquitin ligase Smurf1は,分解のためのMEKK2をターゲットにすることで,骨格細胞の活動と骨の恒常性を制御します

Motozo Yamashita1, Sai-Xia Ying, Gen-Mu Zhang

  • 1Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

Cell
|April 12, 2005
PubMed
まとめ

Smurf1は,MEKK2の分解をターゲットにすることで,オステオブラストの活動を抑制します. Smurf1の喪失は,骨形態遺伝性タンパク質 (BMP) に対するオステオブラストの反応が強化されたため,マウスの骨質を増加させる.

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