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Updated: Jul 15, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
11:36

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing

Published on: July 3, 2016

CTX-Mβ-ラクトマゼの反応座標に沿った構造,機能,抑制

Yu Chen1, Brian Shoichet, Richard Bonnet

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143-2240, USA.

Journal of the American Chemical Society
|April 14, 2005
PubMed
まとめ

抗生物質耐性の主要な原因であるCTX-M酵素は,X線結晶学を用いて研究されました. 研究者らは,重要な構造的変化と新しい阻害機構を特定し,耐性細菌に対する新しい薬剤設計の道を開いた.

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