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Updated: May 8, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

治療戦略としてBRCA変異細胞におけるDNA修復欠陥を標的とする

Hannah Farmer1, Nuala McCabe, Christopher J Lord

  • 1Cancer Research UK Gene Function and Regulation Group, London, UK.

Nature
|April 15, 2005
PubMed
まとめ

BRCA1またはBRCA2遺伝子の機能障害は,がん細胞をPARP阻害剤に敏感にする. これは,Poly (ADP-リボース) ポリメラーゼ (PARP) の活性を阻害することで,DNAの修復が妨げられ,細胞死につながり,新しいがん治療戦略が示唆されるため起こります.

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