メタボリックシンドロームとは
Robert H Eckel1, Scott M Grundy, Paul Z Zimmet
1Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA. Robert.Eckel@UCHSC.edu
Lancet (London, England)
|April 20, 2005
まとめ
肥満に関連したメタボリックシンドロームは,インスリン抵抗性と炎症を伴う. 体重減少などのライフスタイルの変化が鍵であり,II型糖尿病や心血管疾患を予防するために,高リスクの個人に薬を投与します.
科学分野:
- メタボリック障害 メタボリック障害
- 肥満に関する研究
- 心血管の健康についてです.
背景:
- メタボリックシンドロームは,肥満率の上昇とますます結びついている一般的な疾患です.
- 現在の定義は様々ですが,統一されたグローバルな定義が期待されています.
- 重要な病理生理学的要因には,インスリン抵抗性,過度の脂肪酸流動,および炎症性状態が含まれます.
研究 の 目的:
- メタボリックシンドロームをめぐる懸念が高まっていることを強調するためです.
- インスリン抵抗性や炎症を含む,根本的な病理生理学について議論する.
- 2型糖尿病と心血管疾患のリスクが増加したため,治療的注意の必要性を強調する.
主な方法:
- メタボリックシンドロームの病理生理学に関する現在の理解のレビュー.
- 肥満,インスリン抵抗性,および炎症との関連の分析.
- 2型糖尿病および心血管疾患の危険因子の評価.
主要な成果:
- メタボリックシンドロームは,肥満と強く関連しています.
- インスリン抵抗性と炎症を誘発する状態は,その発達の中心にある.
- メタボリックシンドロームを持つ個人は,2型糖尿病や心血管疾患のリスクが高まります.
結論:
- メタボリックシンドロームの効果的な管理は極めて重要です.
- 体重減少と身体活動の増加は,主な介入です.
- 2型糖尿病や心血管疾患などの関連リスクを管理するために,薬理学的介入が必要になる可能性があります.
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