関連する実験動画

Updated: Jul 25, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

ベータアレスティンによる受容体信号の変換

Robert J Lefkowitz1, Sudha K Shenoy

  • 1Howard Hughes Medical Institute, Durham, NC 27710, USA. lefko001@receptor-biol.duke.edu

Science (New York, N.Y.)
|April 23, 2005
PubMed
まとめ

細胞シグナル伝達に不可欠な7つのトランスメブラン受容体は,ベータアレスティンを用いて細胞プラズマ複合体を募集し活性化します. この経路は,細胞の運動性,化学反応,アポトーシスを調節し,新しいシグナル伝達機構を明らかにします.

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Cotranslational Protein Translocation

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Sec61 channel partners for cotranslational translocation
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Insertion of Single-pass Transmembrane Proteins in the RER

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Multi-pass Transmembrane Proteins and β-barrels

In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
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Amplifying Signals via Second Messengers

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Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...
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Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...