Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

34.0K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
34.0K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

7.3K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
7.3K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

7.6K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
7.6K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.4K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.4K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.8K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.8K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

6.0K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
6.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Cost of Idling: Skeletal Muscle Myosin ATPase Dysfunction and the Energetic Basis of Exercise Intolerance in HFrEF.

Circulation. Heart failure·2026
Same author

NgBR controls hepatic adiponectin signaling competence through KAT7-dependent chromatin regulation.

bioRxiv : the preprint server for biology·2026
Same author

A novel subset of hepatocytes is simultaneously gluconeogenic and <i>de novo</i> lipogenic in the fed state and is naturally insulin resistant.

bioRxiv : the preprint server for biology·2026
Same author

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue.

Nature communications·2026
Same author

Phase 2 study of azacitidine plus pembrolizumab as second-line treatment in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma.

The oncologist·2026
Same author

Brain Nutrient Sensing: A Unifying Framework.

Annual review of physiology·2025

関連する実験動画

Updated: May 5, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

97.6K

下垂体K ((ATP) 経路は,肝臓のグルコース生成を制御する.

Alessandro Pocai1, Tony K T Lam, Roger Gutierrez-Juarez

  • 1Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Nature
|April 23, 2005
PubMed
まとめ

低体内K ((ATP)) チャンネルを活性化すると,肝臓のグルコース生成を抑制することで,血糖値を下げます. この脳肝経路の障害は,糖尿病性高血糖症に寄与する.

さらに関連する動画

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

12.6K
Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
08:01

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice

Published on: May 16, 2021

5.6K

関連する実験動画

Last Updated: May 5, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

97.6K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

12.6K
Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
08:01

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice

Published on: May 16, 2021

5.6K

科学分野:

  • 神経科学は神経科学である.
  • メタボリック研究
  • エンドクリノロジー エンドクリノロジー

背景:

  • 肥満は,世界中で2型糖尿病の流行を促しています.
  • 糖尿病における高血糖症は,肝臓におけるグルコン生成の増加と関連しています.
  • 中央下垂体では,エネルギーバランスと肝臓のグルコース出力を調節する信号を統合する.

研究 の 目的:

  • 血糖代謝における下垂体ATP感受性カリウム (K(ATP)) 経路の役割を調査する.
  • 視床下部のK (((ATP)) チャンネル活性化が肝臓のグルコネオゲネシスに影響するかどうかを判断する.
  • 糖尿病の高血糖症に対する中枢神経系-肝臓回路の貢献を調査する.

主な方法:

  • 基底中下垂体におけるK (((ATP) チャンネルの活性化.
  • 基底下垂体の中央部にK (((ATP)) チャンネルブロッカーを注入する.
  • ヴァガス神経の肝臓分岐の切除手術である.
  • K ((ATP)) 経路のSUR1サブユニットがないマウスにおけるグルコース代謝の分析.

主要な成果:

  • 低体内K (((ATP)) 経路の活性化により,肝臓のグルコン生成を阻害することにより,血糖値を下げました.
  • K (((ATP) 経路を遮断したり,迷走神経を切断したりすると,肝臓のグルコース産生に対する中枢インスリンの影響は否定される.
  • SUR1サブユニットが欠けていたマウスは,グルコン生成に対するインスリン抑制効果に対して抵抗性を持っていた.

結論:

  • 視床下部のK (((ATP)) 経路は通常,肝臓のグルコネオゲネシスを抑制する.
  • K ((ATP) チャンネルを含む中枢神経系-肝臓回路の機能障害は,糖尿病性高血糖症に寄与する.
  • 低体内K ((ATP) チャンネルをターゲットにすることで,2型糖尿病の管理のための新しい治療戦略を提供することができる.