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Sox2は,哺乳類の内耳の感覚器官の発達に必須です
Amy E Kiernan1, Anna L Pelling, Keith K H Leung
1MRC Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK.
Nature
|April 23, 2005
まとめ
転写因子SOX2は,内耳の発達に不可欠であり,感覚毛とサポート細胞を特定します. マウス変異体におけるその欠如または減少は,重度の聴覚とバランスの欠損につながる.
科学分野:
- 発達生物学 発達生物学とは
- 神経科学は神経科学である.
- 遺伝学 遺伝学とは
背景:
- 内耳の感覚毛細胞とサポート細胞は,聴覚とバランスの維持に不可欠です.
- 共通の祖先からの彼らの系統の仕様には,十分に理解されていない分子機構が含まれています.
研究 の 目的:
- 内耳の発達と感覚細胞の分化における転写因子SOX2の役割を調査する.
- 特定のマウス変異体における聴覚とバランスの障害の分子基礎を解明する.
主な方法:
- 聴覚とバランスの欠陥が顕著な2つのアレル性マウス変異体 (LccとYsb) の分析.
- ミュータントマウスと野生型のマウスの内耳の形状と感覚細胞の分化を調べた.
- 内耳発達中のSOX2およびMath1 (Atoh1) 遺伝子発現パターンの評価.
主要な成果:
- Lcc/LccマウスはSOX2発現を欠くため,前感官領域の確立に失敗し,内耳の重度の変形を引き起こします.
- Ysb/YsbマウスはSOX2発現が低下し,毛細胞の異常な発育につながる.
- Math1の表現はLcc変異体には存在しないが,SOX2はMath1変異体には存在し,SOX2がMath1.1の上流に作用することを示す.
結論:
- SOX2は,内耳前感官領域の発達と,毛細胞とサポート細胞の両方の分化に不可欠です.
- SOX2は,内耳の感覚細胞の発達を制御する遺伝的階層において,Math1より上流に機能する.
- SOX2の調節不良は,先天的な聴覚とバランスの障害と直接関連しています.
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