幹細胞のコミットメントの複雑な地図作成

¹Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

|April 27, 2005

血液形成性幹細胞 (HSC) は,Flt3受容体を通して初期の細胞運命を約束する. この受容体は,HSCが赤血球とメガカリオ細胞になる可能性を失い,リンパ球の祖先に微分化する最早のポイントをマークします.

血液学ヘマトロジ
発達生物学発達生物学について
幹細胞生物学幹細胞生物学

多能血液形成性幹細胞 (HSC) は,すべての血液細胞タイプに分化するユニークな能力を有しています.
HSCにおける早期の系統結合を制御する正確な分子メカニズムを理解することは,再生医療と血液学的疾患の治療において極めて重要です.

関連する概念動画

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Cancer cell·2024

Development (Cambridge, England)·2024

Nature communications·2024

Cell stem cell·2023

Same journal

Same journal

Same journal

Same journal

Same journal

Same journal

関連する実験動画

幹細胞のコミットメントの複雑な地図作成

関連する概念動画

関連する実験動画

幹細胞のコミットメントの複雑な地図作成

関連する概念動画

関連する実験動画

幹細胞のコミットメントの複雑な地図作成

科学分野:

背景:

関連する概念動画

関連記事

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model.

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.

A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.

Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation.

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence.

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

LEF1 and niche factors determine T cell stemness across chronic diseases.

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

関連する実験動画

幹細胞のコミットメントの複雑な地図作成

科学分野:

背景:

関連する概念動画

関連記事

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model.

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation.

A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.

Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation.

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence.

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

LEF1 and niche factors determine T cell stemness across chronic diseases.

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.