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関連する概念動画

Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

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関連する実験動画

Updated: Jul 12, 2026

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
09:03

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

熱的に閉ざされたリポソーム

Wen-Hua Chen1, Steven L Regen

  • 1Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

Journal of the American Chemical Society
|May 5, 2005
PubMed
まとめ

熱門リポソーム (TGL) は,孔を形成するアンフィフィールと温度に敏感なリポソームを組み合わせている. 41°C以上では,TGLは閉じ込められた溶液を放出しますが,この温度以下では,放出が著しく減少します.

科学分野:

  • バイオマテリアル科学 バイオマテリアル科学
  • 薬物の配送システムです.
  • ナノテクノロジー ナノテクノロジー

背景:

  • 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) で構成されたリポソームは,41°Cで相変化を示す.
  • 毛穴を形成するアンフィフィルは,脂質二重層を不安定化させることができます.
  • 制御放出システムは,標的型療法において極めて重要です.

研究 の 目的:

  • 熱門リポソーム (TGL) の開発と特徴付け.
  • TGLから温度に依存する水性溶液の放出を調査する.
  • 治療薬の投与におけるTGLの可能性を調査する.

主な方法:

  • リジン,ホリック酸,精子から孔を形成するアンフィフィール (化合物1) の合成.
  • DPPCを使用してリポソームの準備.
  • 化合物1をDPPCリポソームに組み込み,TGLを形成する.
  • 異なる温度でTGLからカルボキシフローレスケインの流出を測定する.

主要な成果:

  • 化合物1は,DPPCリポソームで41°C以上の相移行温度で,効果的に毛穴を形成した.

さらに関連する動画

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

関連する実験動画

Last Updated: Jul 12, 2026

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
09:03

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

  • 41°C以上において,有意なカルボキシフローレスセインの流出が観察されました.
  • 流出率は41°C以下に大幅に低下し,温度調整による放出を示した.
  • 結論:

    • TGLは調節可能な,温度に依存する溶液の放出を示しています.
    • 開発されたTGLシステムは,制御され,標的化された薬物投与アプリケーションの有望性を示しています.
    • TGLsの in vivo 効果と治療の可能性を調査するために,さらなる研究が必要である.