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関連する概念動画

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

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関連する実験動画

Updated: May 7, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

エピスタシスとバランスの取れたポリモルフィズムが,複雑な特性の変異に影響を与える.

Juergen Kroymann1, Thomas Mitchell-Olds

  • 1Max Planck Institute for Chemical Ecology, Department of Genetics & Evolution, Hans-Knoell-Str. 8, D-07745 Jena, Germany. kroymann@ice.mpg.de

Nature
|May 6, 2005
PubMed
まとめ

些細な効果の定量的な特質ロシ (QTL) は,複雑な特質に大きく貢献する. この研究では,Arabidopsis thalianaの小さな間隔で2つの成長率QTLを発見し,複雑な遺伝的相互作用と潜在的なバランス選択を明らかにしました.

科学分野:

  • 植物遺伝学 植物遺伝学
  • 定量的な特徴 遺伝学 遺伝学
  • 集団遺伝学 人口遺伝学

背景:

  • 複雑な特徴は,多数の遺伝子 (多遺伝子) によって影響を受けますが,小効果の定量的な特徴の場所 (QTL) はまだ研究されていません.
  • 複雑な特徴の遺伝的構造を理解することは,農業や医学などの分野にとって極めて重要です.

研究 の 目的:

  • アラビドプシス・タリアナの小さな染色体間隔内の遺伝的複雑性を調査するために.
  • 成長率とそれらの相互作用のための定量的な特性の位置 (QTL) を特定し,特徴づけること.

主な方法:

  • アラビドプシス・タライアナの1センチモルガンの染色体間隔の解剖.
  • 異なる接続の間の間隔内の歴史的シーケンスポリモルフィズム解析.
  • 成長率QTLの特定と,それらのエピスタティック相互作用の評価.

主要な成果:

  • 210キロベース領域内で2つの成長率のQTLが特定され,小さなゲノム領域における高い遺伝的複雑性を示した.
  • 両方のQTLはエピスタシスを示し,その効果は遺伝的背景に依存していた.
  • 単一の遺伝子にマッピングされた1つのQTLは,コンテキストに依存する現象的効果を持つバランスセレクションのヌクレオチドシグネチャーを示しています.

さらに関連する動画

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

関連する実験動画

Last Updated: May 7, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

結論:

  • この発見は,定量的な特性の変異のための高度にポリジェニックなアーキテクチャを示唆し,以前のドキュメントを上回る.
  • 非中性エピスタティックポリモルフィズムは,複雑な特徴の遺伝的多様性において重要な役割を果たす可能性があります.
  • この研究は,複雑な特性を理解するために,小効果のQTLと遺伝子環境相互作用を考慮することの重要性を強調しています.