コカイン使用者の間で冠動脈動脈瘤の有病率の増加
Aaron Satran1, Bradley A Bart, Christopher R Henry
1Department of Internal Medicine and Division of Cardiology, Hennepin County Medical Center, Minneapolis, USA.
Circulation
|May 11, 2005
まとめ
コカインの使用は,若年成人における冠動脈動脈瘤 (CAA) のより高い罹患率と関連しています. この研究では,コカイン使用者の30.4%がCAAを有しており,対照群の7.6%と比較して,コカインがCAA形成を促進することを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 血管医学 血管医学とは
- 毒理学 毒理学 毒理学
背景:
- コカインの乱用は,様々な心血管系の合併症と関連しています.
- 冠動脈動脈瘤 (CAA) はまれで,典型的には動脈硬化症や川崎病に関連しています.
- 以前の観察では,若いコカイン使用者におけるCAAが認められ,さらなる調査を促した.
研究 の 目的:
- コカイン使用歴のある個体における冠動脈動脈瘤 (CAA) の有病率を決定する.
- コカイン使用者と冠動脈血管図を施した対照群のCAA率を比較する.
主な方法:
- 遡及的分析では,112人のコカイン使用者と,既存の血管検査データベースから採取した対照群を比較した.
- 冠動脈血管図は,3人の盲目の読者によって独立してレビューされました.
- 心血管疾患のリスク要因を含む臨床的,人口統計的データを分析した.
主要な成果:
- コカイン使用者はより若い (平均年齢44歳),主に男性 (80%) と喫煙者 (95%) でした.
- CAAの罹患率は,コカイン使用者 (30.4%) と対照群 (7.6%) (P<0.001) に比べて,著しく高かった.
- コカインの使用は,単変数および多変数分析の両方でCAAの強力な予測因子として特定されました.
結論:
- この研究は,コカイン使用と冠動脈動脈瘤 (CAA) の間の最初の報告された関連性を確立しています.
- 若いコカイン使用者におけるCAA (30.4%) の高い罹患率は予想外です.
- コカインの使用はCAAの発症に寄与し,潜在的に心筋梗塞のリスクを増やす可能性があります.
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