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関連する概念動画

Gap Junctions01:37

Gap Junctions

Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
Ammeter01:11

Ammeter

An ammeter is a current measuring instrument. In the circuit, it is represented by the symbol A. The ammeter is placed in series with the device or component to measure the current. A series connection is used because objects in series have the same current passing through them. If a circuit has multiple resistors and the current needs to be measured in each resistor, the number of ammeters required depends on whether the circuit is in series or parallel.
When an ammeter is used to measure the...
Mutual Inductance01:24

Mutual Inductance

Inductance is the property of a device that tells us how effectively it induces an emf in another device. In other words, it is a physical quantity that expresses the effectiveness of a given device.
When two circuits carrying time-varying currents are close to one another, the magnetic flux through each circuit varies because of the changing current in the other circuit. Consequently, an emf is induced in each circuit by the changing current in the other. Therefore, this type of emf is called...
Instrument Transformers01:23

Instrument Transformers

Instrument transformers, comprising voltage transformers (VTs) and current transformers (CTs), play crucial roles in power substations by providing isolated replicas of current or voltage for measurement and protection purposes. Voltage transformers reduce the primary voltage to levels suitable for relay operation and measurement, while current transformers scale down the primary current. The primary winding of a current transformer often consists of a single turn, achieved by threading the...
Line Protection with Impedance Relays01:27

Line Protection with Impedance Relays

Coordinating time-delay overcurrent relays in complex radial systems and directional overcurrent relays in multi-source transmission loops can be challenging. Impedance relays address these issues by responding to the voltage-to-current ratio, specifically measuring the apparent impedance of a line. These relays become more sensitive during faults as current increases and voltage decreases, thereby reducing the apparent impedance.
Under normal conditions, low load currents keep the measured...
Differential Relays01:20

Differential Relays

Differential relays are used to protect generators, buses, and transformers by comparing electrical quantities at different points. When a fault occurs, the difference in current between the two points triggers the relay to operate, opening the circuit breaker. Under normal conditions, the current entering (i1) and leaving (i2) a generator are equal. When a fault occurs, however, these currents become unequal, and the difference current flows in the relay operating coil, causing the relay to...

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関連する実験動画

Updated: Jul 11, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

シナプトタグミン: シナプス胞の表面にあるカルシウムセンサー.

N Brose1, A G Petrenko, T C Südhof

  • 1Department of Neurochemistry, Max-Planck-Institute for Psychiatry, Martinsried, Germany.

Science (New York, N.Y.)
|May 15, 1992
PubMed
まとめ

シナプトタグミンは,シナプス胞のタンパク質であり,カルシウムと負の電荷を持つリンパ脂質を結合します. 神経伝達物質の放出に不可欠なこのカルシウム結合は,シナプトタグミンに依存しています.

科学分野:

  • 神経科学は神経科学である.
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • ニューロン通信は,シナプスベシクルのカルシウム依存エクソサイトーシスによる神経伝達物質の放出に依存しています.
  • カルシウムの流入とシナプス胞の融合を結びつける正確な分子機構は,ほとんど不明のままである.

研究 の 目的:

  • シナプトタグミンのシナプチウム信号の媒介におけるシナプチスベシクルエクソサイトーシスにおけるシナプチスベシクルエクソサイトーシスの作用を調査する.
  • シナプトタグミンのカルシウムおよびフォスフォリピドとの分子相互作用を解明する.

主な方法:

  • シナプトタグミンへのカルシウムの結合を研究するための生化学分析.
  • シナプトタグミンの負の電荷を持つフォスフォリピドとの相互作用の分析.
  • シナプトタグミンのオリゴーマー構造がタンパク質分裂を用いてカルシウム結合に及ぼす影響を調査する.

主要な成果:

  • シナプトタグミンは,特に生理学的濃度でカルシウムと結合する.
  • カルシウムの結合は,負の電荷を持つフォスホリピドの複合体で起こります.
  • カルシウムの結合は,シナプトタグミンの無傷なオリゴメリック構造に依存し,タンパク質分裂によって廃止されます.

さらに関連する動画

Manufacturing Simple and Inexpensive Soil Surface Temperature and Gravimetric Water Content Sensors
08:49

Manufacturing Simple and Inexpensive Soil Surface Temperature and Gravimetric Water Content Sensors

Published on: December 21, 2019

In Situ Soil Moisture Sensors in Undisturbed Soils
08:20

In Situ Soil Moisture Sensors in Undisturbed Soils

Published on: November 18, 2022

関連する実験動画

Last Updated: Jul 11, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Manufacturing Simple and Inexpensive Soil Surface Temperature and Gravimetric Water Content Sensors
08:49

Manufacturing Simple and Inexpensive Soil Surface Temperature and Gravimetric Water Content Sensors

Published on: December 21, 2019

In Situ Soil Moisture Sensors in Undisturbed Soils
08:20

In Situ Soil Moisture Sensors in Undisturbed Soils

Published on: November 18, 2022

結論:

  • シナプトタグミンは,シナプス胞エクソサイトーシスの過程で重要なカルシウムセンサーとして機能します.
  • この結果は,シナプトタグミンが協力的なカルシウム受容体として作用し,カルシウム信号と膜融合イベントを統合することを示唆しています.