髪染料の個人使用とがんのリスク:メタ分析
Bahi Takkouche1, Mahyar Etminan, Agustín Montes-Martínez
1Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. mrbahi@usc.es
JAMA
|May 26, 2005
まとめ
このシステマティック・レビューでは,パーソナルヘア染料の使用と,全体的ながんリスクの有意な増加を結びつける有力な証拠は見つかりませんでした. しかし,潜在的関連を示す血液形成性および他の特定の癌については,さらなる調査が推奨されます.
科学分野:
- エピデミオロジー エピデミオロジー
- 腫瘍学 腫瘍学
- 毒理学 毒理学 毒理学
背景:
- 最近の研究では,染料の使用とがんのリスクとの潜在的な関連が示唆されています.
- これは公衆の懸念を引き起こし,科学的評価を要求している.
研究 の 目的:
- 個人用ヘア染料の使用とがんリスクとの関連に関する疫学的証拠を体系的に評価する.
主な方法:
- 複数のデータベース (MEDLINE,EMBASE,LILACS,ISI Proceedings) で包括的な文献検索が行われました.
- 対象となったのは,職業的曝露を除いて,個人用ヘア染料の使用とがんリスクに関するコホートおよびケース・コントロール研究であった.
- データ抽出は,相対リスクの推定値と信頼区間に焦点を当て,様々な癌のタイプを別々に分析した.
主要な成果:
- プール分析では,髪染料の使用者の間で乳がん (RR 1.06) または膀がん (RR 1.01) のリスクが有意に増加していないことが示されました.
- 血液形成性がんのリスクがわずかに増加することが観察された (RR 1.15).
- 脳のがん,卵巣がん,唾液腺がんに関する限られた研究で,永久的または広範な染料の使用による効果は認められず,リスクが高いことが示されました.
結論:
- 全体的に,個人用染料の使用に関連した癌リスクの有意な増加を示す強力な証拠はありません.
- 限られた研究で潜在的な関連性を示す血液形成がんやその他の部位については,さらなる研究が必要である.
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