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Updated: Jul 11, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

選択的,不可逆的なキナーゼ阻害剤の構造バイオインフォマティクスベースの設計

Michael S Cohen1, Chao Zhang, Kevan M Shokat

  • 1Program in Chemistry and Chemical Biology, and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-2280, USA.

Science (New York, N.Y.)
|May 28, 2005
PubMed
まとめ

選択性キナーゼ阻害剤の設計は,活性サイトが保存されているため,困難です. 研究者らは,p90リボソームタンパク質S6キナーゼ (RSK) の2つの重要なアミノ酸を特定し,強力で選択的阻害剤の設計を可能にしました.

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity09:16

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

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