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Updated: Aug 17, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

アンカーレスプリオンタンパク質は,臨床的なスクラピー症候群なしに,感染性アミロイド疾患を引き起こす

Bruce Chesebro1, Matthew Trifilo, Richard Race

  • 1Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. bchesebro@niaid.nih.gov

Science (New York, N.Y.)
|June 4, 2005
PubMed
まとめ

プリオンタンパク質のGPIアンカーは,プリオン病に影響を与える. アンカーレスPrPからのアミロイドプラークは脳損傷を引き起こしたが,症状は最小限であり,アンカーレスとワイルドタイプのPrPの組み合わせは病気を加速した.

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Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain

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Protein Misfolding Cyclic Amplification of Prions

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