腸内皮質細胞の急激な周回:寄生虫の追放の新たなメカニズム

Laura J Cliffe¹, Neil E Humphreys, Thomas E Lane

¹Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

Science (New York, N.Y.)

|June 4, 2005

まとめ

大腸は,免疫信号によって制御されるプロセスである上皮細胞の周回数を増加させることで,トリチュリスのような寄生虫を排出します. この"上皮エスカレーター"メカニズムは,腸の障壁を強調しています.

科学分野:

免疫学免疫学とは
胃腸内科胃腸内科
細胞生物学細胞生物学

背景:

腸内皮質障壁は,病原体に対する防御に不可欠です.
トリチュリスのような腸内線虫は,世界中で広く存在しています.
粘膜表面における宿主-病原体の相互作用を理解することは,極めて重要です.

研究の目的:

腸内ニマトダスを排出する際の上皮細胞の転移の役割を調査する.
腸内における上皮細胞の動きを制御する免疫メカニズムを特定する.

主な方法:

大腸における上皮細胞の転機率を研究した.
サイトカインインタールイキン-13 (IL-13) とキモカインCXCL10.10の役割を研究した.
トリチュリス感染の利用モデル.

主要な成果:

大腸における上皮細胞の周回量の増加は"上皮エスカレーター"として作用し,Trichuris.
皮質細胞の動きは,免疫因子,特にIL-13とCXCL10によって調節されます.
このメカニズムは,重要なホスト防衛戦略を表しています.

結論:

皮質細胞の周轉は,腸の寄生虫に対する主体の防御メカニズムである.
IL-13のような免疫サイトカインとCXCL10のようなケモカインは,この排出を調節する上で重要な役割を果たします.
腸内皮質は,粘膜免疫において多機能的な役割を果たします.

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