青少年および成人に使用する5つの成分を併用したテタヌス,ディフテリア, pertussisワクチンです
Michael E Pichichero1, Margaret B Rennels, Kathryn M Edwards
1University of Rochester Medical Center, Rochester, NY 14642, USA. michael_pichichero@urmc.rochester.edu
JAMA
|June 4, 2005
まとめ
テタヌス・ディフテリア5成分無細胞性 pertussis vaccine (Tdap) は,青少年および成人において強い免疫反応を示した. この pertussis ワクチンは,テタヌス・ディフテリア (Td) ワクチンと比較できる安全性プロファイルを示しました.
科学分野:
- 免疫学 免疫学とは
- ワクチン学 ワクチン学
- 公衆衛生は公衆衛生である.
背景:
- 米国で高まる pertussis 症例は,高齢者向けにワクチンを必要とする.
- 乳児 pertussisは,青少年や成人からしばしば契約されています.
研究 の 目的:
- テタヌス・ディフテリア5成分無細胞性 pertussisワクチン (Tdap) の免疫性および安全性を評価する.
- 青少年および成人のTdapワクチンを評価する.
主な方法:
- ランダム化され,ダブルブラインドで,4480人の健康な青少年と成人 (11-64歳) を対象とした比較試験です.
- 参加者は,Tdapまたはテタヌス・ディフテリア (Td) のいずれかのワクチンの単回筋内投与を受けた.
- 免疫反応と有害事象のモニタリングが行われました.
主要な成果:
- TdapとTdのワクチンは,ディフテリアとテタヌスに対する抗体の高濃度を引き起こした.
- Tdapワクチンは,乳児のDTaPワクチンの反応と比較して,百日咳抗原に対する抗体タイターが著しく高かった.
- 局所および全身反応は,Tdap群とTd群の間に類似していました.
結論:
- Tdapワクチンは,青少年および成人における pertussis,テタヌス,およびディフテリア抗原に対する免疫原性である.
- Tdapは,認可されたTdワクチンと同様の安全性プロファイルを示した.
- データは,青少年および成人のTdapの日常的な使用を支持しています.
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