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Updated: Jul 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

(-) -テトラサイクリン合成

Mark G Charest1, Dionicio R Siegel, Andrew G Myers

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Journal of the American Chemical Society
|June 9, 2005
PubMed
まとめ

本研究では,ベンゾ酸から (-) - テトラサイクリンを17段階のエナチオセレクティブ合成により,総収量1.1%を達成した. 主なステップは,効率的な抗生物質生産のためのダイエルス-アルダーサイクル添加とステレオ選択的酸化を含んでいた.

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