関連する実験動画

Updated: Jul 16, 2026

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice
10:55

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

中枢神経系における損傷に関連したダイナミックなミエリン/オリゴデンドロサイト軸突増殖抑制

Jan M Schwab1, Vieri Failli, Alain Chédotal

  • 1Equipe Développement Neuronal, CNRS UMR 7102, Université Pierre et Marie Curie (Paris 6), Paris, France. Jschwab@zeus.bwh.harvard.edu

Lancet (London, England)
|June 14, 2005
PubMed
まとめ

かつて静的と考えられていたミエリンは,中枢神経系 (CNS) の損傷後のアクソン再生を積極的に阻害する. 新しい発見は,反応性ミエリンと変異した軸索が再生に挑戦し,新しい治療戦略が必要であることを明らかにしています.

さらに関連する動画

A Simple Neuronal Mechanical Injury Methodology to Study Drosophila Motor Neuron Degeneration04:18

A Simple Neuronal Mechanical Injury Methodology to Study Drosophila Motor Neuron Degeneration

Published on: July 19, 2017

A Drosophila In Vivo Injury Model for Studying Neuroregeneration in the Peripheral and Central Nervous System09:55

A Drosophila In Vivo Injury Model for Studying Neuroregeneration in the Peripheral and Central Nervous System

Published on: May 5, 2018

関連する概念動画

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...