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ロキナーゼは,血管内皮細胞における高血糖症誘発性プラズミノゲン活性化剤阻害剤-1の発現を媒介する

Yoshiyuki Rikitake1, James K Liao

  • 1Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.

Circulation
|June 16, 2005
PubMed
まとめ

高血糖 (高血糖症) は,ロキナーゼを活性化することにより,プラズミノゲン活性化剤阻害剤-1 (PAI-1) を増加させる. タンパク質キナーゼC (PKC) と酸化ストレスを含むこの経路は,糖尿病に関連する心血管疾患の潜在的な治療目標を提供します.

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