低体温は,除細動の成功と心房細動からの蘇生結果を改善します
Kimberly A Boddicker1, Yi Zhang, M Bridget Zimmerman
1Cardiovascular Center, College of Medicine, University of Iowa, Iowa City, USA.
Circulation
|June 16, 2005
まとめ
誘発性低体温症は,心停止の生存者における除細動の成功と蘇生結果を改善します. 中度から重度の低体温症は,心房細動 (VF) の後の成功した蘇生の可能性を大幅に高めます.
科学分野:
- 心臓病学 心臓病学
- 緊急医療 緊急医療
- 生理学 生理学とは
背景:
- 誘発性低体温症は,心停止の生存者の神経学的結果を改善するために推奨されます.
- 静脈細動 (VF) が再発した患者の除細動と蘇生に対する低体温の影響に関するデータは限られている.
研究 の 目的:
- 心停止のモデルにおいて,除細動の成功と蘇生の結果に対する様々な度の低体温の影響を調査する.
主な方法:
- 32匹の豚は,ノルモサーミアと軽度,中度,または重度の低体温群に分けられました.
- Ventricular fibrillation (VF) が誘発され,その後,心肺蘇生 (CPR) が行われずに8分経過した.
- デフィブリレーションの成功と自発循環の回復 (ROSC) は,CPR後に評価されました.
主要な成果:
- 最初のショック時の除細動の成功率は,中程度の低体温症のグループ (6/8) で,ノルモサーミア (1/8) と比較して,有意に高かった.
- すべての低体温症グループは,ノーマル熱症と比較して,遅期除細動のために少数のショックを必要としました.
- 自発的循環の再開は,正常体温の動物0/8で,軽度の低体温の動物3/8で,中度の動物7/8で,重度の低体温の動物5/8で起こりました.
結論:
- 中度および重度の低体温症は,誘発性心房細動 (VF) の環境で,除細動の成功と蘇生結果を大幅に改善します.
- この有益な効果は,心肺蘇生中の冠動脈 perfusion pressure の変化に起因するものではありません.
- 心筋の機械的,代謝的,または電気生理学的性質の変化は,おそらく低体温のポジティブな影響を媒介する.
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