Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Acupuncture does not work and has no place in science-based medicine.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

Molecular oncology·2025
Same author

European cancer research requires renewed urgency.

Nature cancer·2025
Same author

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe.

Molecular oncology·2025
Same author

Academia and society should join forces to make anti-cancer treatments more affordable.

Molecular oncology·2024
Same author

Transforming lung cancer types.

Science (New York, N.Y.)·2024

関連する実験動画

Updated: Jun 19, 2026

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

肺がんのための幹細胞?

Anton Berns1

  • 1Division of Molecular Genetics and Centre of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Cell
|June 18, 2005
PubMed
まとめ
この要約は機械生成です。

研究者は,肺アデノカルシノーマを引き起こす幹細胞を含む特定の肺ニッチを特定しました. これらの幹細胞は,K-rasによって活性化されると,腫瘍の発達を駆動し,肺がんの新たな治療目標を提供します.

さらに関連する動画

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
07:39

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

関連する実験動画

Last Updated: Jun 19, 2026

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
07:39

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

科学分野:

  • 肺医学は肺を治療する薬です.
  • がん生物学 がん生物学
  • 幹細胞の研究についてです.

背景:

  • 腫瘍の発達は,幹細胞と密接に関連しています.
  • 肺がんにおける幹細胞の区画を特定することは,高い発生率と再発率のために非常に重要です.

研究 の 目的:

  • 肺アデノカルシノーマ発症に起因する特定の幹細胞ニッチを特定する.
  • これらの幹細胞が正常な肺ホメオスタシスと癌の進行における役割を調査する.

主な方法:

  • 成人マウスの肺における,支氣管管交差点からの幹細胞の局所化と分離.
  • 特定された幹細胞のインビトロ増殖と分化.
  • 腫瘍性K-rasタンパク質による幹細胞活性化の分析.

主要な成果:

  • 特定の幹細胞のニッチは, bronchioalveolar 管の交差点で特定されました.
  • これらの幹細胞は, in vitro で,成功裏に増殖,増殖,分化されました.
  • 腫瘍性K-rasによるこれらの幹細胞の活性化が観察され,アデノカルシノーマ発症と関連付けられました.

結論:

  • ブロンキオアルベオラ管の交差点には,肺腺癌の発生源である可能性が高い幹細胞が宿っている.
  • K-rasによるこれらの幹細胞の活性化を理解することは,肺がんの発症の洞察を提供します.
  • この研究は,肺がんに対する新しい治療戦略の道を開きます.