アポと基質の模倣状態におけるmus-ms酵素運動の保存

Heather Beach1, Roger Cole, Michelle L Gill

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

まとめ

核磁共振 (NMR) のスピン・リラクゼーション実験では,リボヌクレアゼA (RNase A) のダイナミクスは,そのアポ形式であれ,基板模倣に結合するであれ,一貫していることが明らかになりました. リガンド結合は酵素の構造変化を安定させますが,誘導することはありません.

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