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Staphylococcus aureus内心炎:医学進歩の結果として生じている

Vance G Fowler¹, Jose M Miro, Bruno Hoen

¹Duke University Medical Center, Durham, NC 27710, USA. vance.fowler@duke.edu

|June 24, 2005

まとめ

黄金球菌 (Staphylococcus aureus) は,世界的に感染症性内心炎 (IE) の主要な原因である. この研究は,S aureus IEとメチチリン耐性S aureus (MRSA) IEの患者特性の有意な地域差異を強調しています.

科学分野:

感染症感染症は感染症です.
エピデミオロジーエピデミオロジー
心臓病学心臓病学

背景:

Staphylococcus aureusによって引き起こされる感染症性内心炎 (IE) は,世界的な健康上の重大な懸念事項である.
S. aureus IEの世界的な流行と地域的な変動は,ほとんど文書化されていないままです.
これらのパターンを理解することは,効果的な公衆衛生戦略にとって極めて重要です.

研究の目的:

医療関連のS aureus IEとメチチリン耐性S aureus (MRSA) IEの国際的発生を調査する.
S. aureus IEの患者の人口統計と臨床特徴の地域差を分析する.

主な方法:

確固たるIEを有する1779人の患者を対象とした前向きな観察コホート研究.
2000年から2003年にかけての内心内膜炎前向きコホート研究 (ICE-PCS) 国際協力 (ICS-Prospective Cohort Study) による16カ国の39の医療センターから収集されたデータ.
病院内死亡率は,主なアウトカムメーターでした.

主要な成果:

黄金球菌 (Staphylococcus aureus) は,IEで最も一般的な病原体 (症例の31.4%) として特定されました.
医療関連のS aureus IEは,地域による有意な変動 (25.9%から54.2%) を伴って,流行していました.
メチチリン耐性S aureus (MRSA) のIE発生率は地域によって著しく異なっており,米国とブラジルで最も高かった.

結論:

黄金球菌 (Staphylococcus aureus) は,世界中で感染性心内炎の主要な原因である.
S aureus IEの患者の特徴には,地域差が大きい.
これらの観察された地域差の根本的な理由を解明するために,さらなる研究が必要である.

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