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関連する概念動画

Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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関連する実験動画

Updated: Jul 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

マルチレスポンシブ"インテリジェント"コアシェルマイクロジェルの構造

Ingo Berndt1, Jan Skov Pedersen, Walter Richtering

  • 1Institute of Physical Chemistry, University of Aachen, Landoltweg 2, D-52056 Aachen, Germany.

Journal of the American Chemical Society
|June 30, 2005
PubMed
まとめ

この研究では,温度に2倍敏感なコアシェルのマイクロゲルを調査し,ポリマーの相互作用が腫れにどのように影響するかを明らかにしました. コアとシェルは相互に影響し合う.

科学分野:

  • ポリマー科学と工学 ポリマー科学と工学
  • マテリアルサイエンス 材料科学
  • ソフトマター物理学 ソフトマター物理学

背景:

  • コアシェルのマイクロジェルは,調節可能な性質を持つ高度なポリマーネットワークです.
  • 温度に敏感なポリマーは,特定の温度で体積相変異 (LCST) を表します.
  • マイクロゲルのコアとシェルの相互作用を理解することは,アプリケーションにとって非常に重要です.

研究 の 目的:

  • 二重温度感受性のコアシェルマイクロゲルの構造的振る舞いを調査する.
  • マイクロゲル寸法におけるコアとシェルの膨張の相互影響を解明する.
  • ポリマーLCSTsに比べて異なる温度調節におけるマイクロゲルの形態を分析する.

主な方法:

  • 小角中性子散射 (SANS) を使用して,マイクロゲル構造を調査しました.
  • データの分析には,新しい普遍的な形状因子モデルが適用されました.
  • 放射線密度プロファイルは,さまざまな温度で決定されました.

主要な成果:

  • 両方の低臨界溶液温度 (LCST) の上では,狭いインターフェイスを持つ2つの箱のプロファイルが観察されました.
  • LCSTの間では,膨らんだ殻が核の次元を拡大した.

さらに関連する動画

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

関連する実験動画

Last Updated: Jul 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

  • 両方のLCSTの下では,殻が核の腫れを制限し,原発状態よりも小さな核につながった.
  • 結論:

    • この研究は,温度感受性のマイクロジェルにおけるコアとシェルの腫れの間に有意な相互影響があることを示しています.
    • 観察された構造の変化は,コアおよびシェルポリマーの独特のLCSTと直接関連しています.
    • これらの発見は,制御された膨張行動を持つ反応性のある材料の設計に関する洞察を提供します.