関連する実験動画

Updated: Jul 17, 2026

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

細胞に浸透するcis-gamma-amino-l-proline由来ペプチドである

Josep Farrera-Sinfreu1, Ernest Giralt, Susanna Castel

  • 1Barcelona Biomedical Research Institute, Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Spain.

Journal of the American Chemical Society
|June 30, 2005
PubMed
まとめ

新しいガンマペプチドは天然のアミノ酸を模倣し,エンドサイトーシス経由で細胞に効率的に侵入します. これらの新種のオリゴマーは,TATペプチドと比較して,毒性が低下し,プロテアゼ耐性を示しています.

さらに関連する動画

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

Cell-Free Protein Synthesis System for Building Synthetic Cells07:43

Cell-Free Protein Synthesis System for Building Synthetic Cells

Published on: April 19, 2024

関連する概念動画

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...