女性における循環中のアンドロゲンレベルと自己報告された性機能
Susan R Davis1, Sonia L Davison, Susan Donath
1Women's Health Program, Department of Medicine, Monash Medical School, Alfred Hospital, Victoria, Australia. susan.davis@med.monash.edu.au <susan.davis@med.monash.edu.au>
JAMA
|July 7, 2005
まとめ
この研究では,低テストステロンと女性の性機能障害の間の直接的な関連は見つかりませんでした. デヒドロエピアンドロステロン硫酸との関連は特定の年齢層で観察されたが,アンドロゲンのレベルが性機能低下を予測するものは1つもない.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 性的健康 性的健康について
- 女性の健康 女性の健康
背景:
- 低テストステロンと女性の性機能不全の間の提案されたリンクには,堅実な証拠がありません.
- 血清アンドロゲン濃度と女性における自己報告された性機能との関係を調査する.
研究 の 目的:
- 性欲/満足度が低い女性の血清アンドロゲン濃度が低いかどうかを判断する.
- 特定の性機能領域とアンドロゲンレベルとの関連を調べる.
主な方法:
- オーストラリアのビクトリア州で18~75歳の女性1021人を対象に横断研究を行った.
- 女性性機能プロファイル (PFSF) を用いて性機能を評価した.
- 計測された血清濃度は,トータル/フリーテストステロン,アンドロステンジオン,およびデヒドロエピアンドロステロン硫酸塩 (DHEA-S) でした.
主要な成果:
- 性機能の低下と低総/自由テストステロンまたはアンドロステンジオンとの間に有意な関連性が見つかりませんでした.
- 45歳以上の女性における性的反応の低下は,低レベルのDHEA-Sと関連している (OR,3.90).
- 18~44歳の女性における性欲,興奮,応答性の低下は,低レベルのDHEA-S (ORは3.86~6.59) と関連している.
結論:
- 単一のアンドロゲンレベルは,女性の性機能不全を確実に予測することはできません.
- DHEA-Sレベルが低い女性のほとんどは,性機能の低下を経験しません.
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