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Updated: Jul 12, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
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リン酸化c-JunとTCF4の相互作用は,腸がんの発症を調節する

Abdolrahman S Nateri1, Bradley Spencer-Dene, Axel Behrens

  • 1Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Nature
|July 12, 2005
PubMed
まとめ

c-Jun N-ターミナルキナーゼ (JNKs) によってプロトオンコプロテインc-Junのリン酸化により,TCF4との相互作用が強化され,腸内腫瘍の成長を促します. この相互作用を阻害すると,腫瘍の発達が減り,WNT駆動の腫瘍発生における重要な規制メカニズムが浮き彫りにされる.

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