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Updated: Jul 9, 2026

Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines
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miRNA,がん,幹細胞の分裂など

Carlo M Croce1, George A Calin

  • 1Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

Cell
|July 13, 2005
PubMed
まとめ

マイクロRNA (miRNA) は,細胞の重要なプロセスを調節する. 異常なmiRNA遺伝子発現は,最近の研究で強調されているように,がんの発達と進行に関与しています.

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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