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Updated: May 3, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
12:08

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry

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単核鉄酵素による抗生物質フォスフォマイシン生物合成に関する構造的洞察

Luke J Higgins1, Feng Yan, Pinghua Liu

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|July 15, 2005
PubMed
まとめ

構造的な洞察は,フォスフォマイシン生物合成における新しい酵素であるヒドロキシプロピルフォスフォン酸エポキシダースが,基質認識と触媒のユニークなメカニズムを使用することを明らかにします. この研究は,非ヘム単核鉄酵素の新しいサブファミリーとしての機能を明らかにしています.

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