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The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genome Copying Errors02:46

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Updated: Jul 9, 2026

Protocols for C-Brick DNA Standard Assembly Using Cpf1
12:03

Protocols for C-Brick DNA Standard Assembly Using Cpf1

Published on: June 15, 2017

人間のc-kitオンコゲン・キット内の推定DNA四重複形成.

Sarah Rankin1, Anthony P Reszka, Julian Huppert

  • 1Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Journal of the American Chemical Society
|July 28, 2005
PubMed
まとめ

c-kitの腫瘍遺伝子のプロモーターにある特定のDNA配列は,安定した四重複構造を形成する. この発見は,ゲノムにそのような構造が少なく存在することを示唆し,がん治療の新たな標的となる可能性がある.

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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture (4C-seq)
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture (4C-seq)

Published on: October 5, 2018

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

関連する実験動画

Last Updated: Jul 9, 2026

Protocols for C-Brick DNA Standard Assembly Using Cpf1
12:03

Protocols for C-Brick DNA Standard Assembly Using Cpf1

Published on: June 15, 2017

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture (4C-seq)
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture (4C-seq)

Published on: October 5, 2018

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

科学分野:

  • ゲノミクスゲノミクスとは
  • 構造生物学 構造生物学とは
  • 腫瘍学 腫瘍学

背景:

  • c-kitの腫瘍遺伝子は,様々ながんに作用する.
  • DNAは,二重ヘリックスを超えた複雑な構造を形成することができる.
  • ゲノム四重複体の流行は完全に理解されていません.

研究 の 目的:

  • c-kit oncogeneプロモーターから特定のDNA配列の構造的性質を調査する.
  • この配列が,生理学的条件下で四重複構造を形成するかどうかを判断する.
  • 配列変化が四重複形成に与える影響を評価する.

主な方法:

  • 核磁共振 (NMR) スペクトロスコーピーは,核磁共振 (NMR) スペクトロスコーピーのスペクトロスコーピーを用います.
  • 円形ダイクロイズム (CD) スペクトルスコピー
  • 融解温度 (Tm) の測定について

主要な成果:

  • DNA配列d ((AGGGAGGGCGCTGGGAGGAGGG) は,安定した4鎖の四重複構造を形成する.
  • この四重複の形成は,生理学的条件下で起こります.
  • グアニンの経路間のわずかなシーケンスの修正により,四重複の形成が防止されました.

結論:

  • c-kit プロモーターには,G-四重複構造を形成できる配列が含まれています.
  • ゲノム四重複の形成は,以前から推測されていたよりも少なくなることがあります.
  • c-kit quadruplexは,c-kitによって引き起こされるがんに対する新たな治療標的となる可能性がある.