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Updated: Jul 10, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
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Par-4は,ドーパミンシグナル伝達とうつ病を結びつけている

Sang Ki Park1, Minh Dang Nguyen, André Fischer

  • 1Department of Pathology, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Cell
|July 30, 2005
PubMed
まとめ

前立腺アポトーシス反応4 (Par-4) は,ドーパミンD2受容体と相互作用することによって,ドーパミンシグナル伝達を調節する. 障害のあるPar-4相互作用は,ドーパミンのシグナル伝達が変化し,マウスのうつ病のような行動が増加する.

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