疫病バクテリアは,感染中に免疫細胞を標的とする
Melanie M Marketon1, R William DePaolo, Kristin L DeBord
1Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
まとめ
疫病細菌 (Yersinia pestis) は,感染中に免疫細胞,主にデンドリット細胞,マクロファージ,中性粒子を注入します. この細菌の戦略は,宿主の免疫反応を無効化し,ペストを引き起こす可能性が高い.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- バクテリア学 バクテリア学
背景:
- 疫病は,Yersinia pestisによって引き起こされる重症の感染症です.
- Yersinia pestisは,III型分泌システムを使用して,エフェクタータンパク質 (Yops) を宿主細胞に注入します.
- 感染中のYersinia pestisの特定の宿主細胞標的は,大部分未確認のままです.
研究 の 目的:
- エフェクタータンパク質の注射のために,Yersinia pestisが標的とする特定の宿主免疫細胞集団を特定する.
- 疫病の間,宿主の免疫反応をYersinia pestisが操作するメカニズムを理解する.
主な方法:
- エフェクター注入を追跡するためにYopβ-ラクタマースハイブリッドタンパク質を使用した.
- 疫病に感染した動物から隔離された生細胞に光染色技術を使用した.
- デンドリット細胞,マクロファージ,中性細胞,Bリンパ球,Tリンパ球を含む様々な免疫細胞の注射頻度を分析した.
主要な成果:
- Yersinia pestisは,ヨップタンパク質の注射のための免疫細胞を優先的に選択しました.
- デンドリット細胞,マクロファージ,中性粒子は,in vivoで最も頻繁に注入された細胞タイプでした.
- Bリンパ球とTリンパ球は,Yersinia pestis.による注射の標的としてめったに用いられませんでした.
結論:
- Yersinia pestisは,重要な免疫細胞集団を積極的に標的として破壊します.
- 免疫細胞にエフェクタータンパク質を注入することで,おそらく宿主の免疫系を無効化する役割を果たします.
- この標的型免疫細胞攻撃は,ペストの病原化に寄与する重要なメカニズムである.
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