LCAT機能の低下は,動脈硬化症の増加と関連しています
G Kees Hovingh1, Barbara A Hutten, Adriaan G Holleboom
1Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Circulation
|August 3, 2005
まとめ
LCAT遺伝子の欠陥を有する個人は,HDLコレステロールが低く,トリグリセリドが高く,心血管疾患のリスクが高まります. LCATをターゲットにすることは,CVDの予防のための新しい戦略を提供することができます.
科学分野:
- バイオケミストリー バイオケミストリー
- 遺伝学 遺伝学とは
- 心血管医学 心血管医学
背景:
- 低HDLコレステロールは,心血管疾患 (CVD) の既知の危険因子です.
- レシチン:コレステロールアシルトランスフェラーゼ (LCAT) 遺伝子変異によるHDLコレステロールの重度の低下がCVDリスクにおける役割は不明である.
- LCAT変異のキャリアにおけるCVDリスクの理解は,LCATを治療目標として明らかにする可能性があります.
研究 の 目的:
- LCAT遺伝子変異と心血管疾患のリスク因子の関連性を調査する.
- LCAT遺伝子欠陥を有する個体における心血管リスクマーカーを評価する.
主な方法:
- 評価された脂質,リポプロテイン,C反応性タンパク質 (CRP),および頸動脈のインティマ・メディア厚さ (IMT).
- LCAT遺伝子変異の47のヘテロジゴトと58の家族対照群を比較した.
- 年齢,性別,アルコール使用量に調整した統計分析.
主要な成果:
- ヘテロジゴットは,HDLコレステロールの36%低下,トリグリセリドの23%増加,CRPの2.1倍増加を示しました.
- コントロールと比較して,ヘテロジゴトの体内 Carotid IMT が有意に増加した (P<0.0015 調整後).
結論:
- LCAT遺伝子の欠陥は,低いHDLコレステロール,高いトリグリセリド,および増加したCRPに関連しています.
- 観察されたIMTの増加は,LCATが動脈硬化から保護することを示唆しています.
- HDLコレステロールを高めるためにLCATをターゲットにすることが,CVDのリスクを減らすための実行可能な戦略である可能性があります.
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