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睡眠による心血管神経調節の変化が,自発的に高血圧になったネズミで観察された

Terry B J Kuo¹, Cheryl C H Yang

¹Institute of Neuroscience, Department of Physiology, Tzu Chi University, Tzu Chi Buddhist General Hospital, Hualien, Taiwan.

|August 3, 2005

まとめ

自発的な高血圧のラットは,覚醒しているときとは異なり,睡眠中に交感性血管運動活動の増加と,睡眠中にバロレフレクスの感受性の低下を示します. 心血管神経調節のこれらの変化は,睡眠を強調しています.

科学分野:

心血管生理学心血管の生理学
スリープ・メディシン (睡眠医学)
神経科学は神経科学である.

背景:

睡眠は,心血管神経調節に大きな影響を与えます.
これらの効果を理解することは,高血圧の管理に不可欠です.

研究の目的:

自発性高血圧ラット (SHR) の睡眠覚醒サイクル中の交感性血管運動活動とバロレフレクスの感受性の変化を調査する.

主な方法:

ポリソムノグラフィは,SHRとウィスター・京都ラット (WKY) に使用されました.
スペクトル解析により,睡眠段階 (活発な覚醒,静かな睡眠,パラドックスな睡眠) が定義された.
交感活動 (BLF) とバロレフレクスの感度 (BrrA, BrrD, BrrHF, BrrLF) を定量化した.

主要な成果:

SHRはすべての州で平均高血圧を維持した.
活発な覚醒の間,SHRとWKYは測定パラメータの違いを示さなかった.
静かな睡眠とパラドックスな睡眠の間,SHRはWKYと比較して,より高いBLFと低いバロレフレクスの感度 (BrrA, BrrD, BrrHF, BrrLF) を示した.

結論:

"自発的に高血圧になったネズミは,睡眠中に交感性血管運動活動の増加を示します.
バロレフレクスの敏感性は,睡眠中にSHRで低下します.
睡眠中の心血管神経調節のこれらの変化は,覚醒時に明らかではありません.

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