カテーテル先と組織温度との差異は,冷却先アブレーションにおいて:左心房アブレーションのガイドに係る関連性
G Keith Bruce1, T Jared Bunch, Mark A Milton
1Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Circulation
|August 10, 2005
まとめ
カテーテル先の温度は,冷やされた先の切除の際に組織温度を正確に反映しません. 微小泡の形成は過熱を示し,無線周波数エネルギーを減らす必要があることを示唆します.
科学分野:
- 心血管の介入 心血管の介入
- 電気生理学 電気生理学
- バイオメディカルエンジニアリング
背景:
- 冷やされた先端のアブレーションは,心律不整症の治療に使用されます.
- 切除時に組織温度を正確に推定することは,安全性と有効性にとって極めて重要です.
- カテーテル先の温度,組織温度,電源,微小泡の形成の関係がよくわかっていない.
研究 の 目的:
- カテーテル先と組織の温度との差異を冷却先アブレーションで調べる.
- 電力,温度,およびマイクロバブル形成の間の相関を調査する.
- 微小泡の形成が組織過熱を確実に予測できるかどうかを判断する.
主な方法:
- ラジオ周波数エネルギーの配送は,9頭の犬に冷却型キャセターを用いて行われました.
- カテーテル先と組織の温度をモニターした.
- マイクロバブル形成を観察するためにパワーが定位され,イントラカルディアックエコーカルディオグラフィーによって導かれました.
- 消去の際にインペデンス変化が記録された.
主要な成果:
- カテーテル先の温度は安定し,組織温度は電力で大幅に上昇した.
- タイプIとタイプIIのマイクロバブルは,重複する温度と電力範囲で形成されます.
- マイクロバブル形成,特にタイプIは,タイプIIよりも低いパワーと温度で発生しました.
- マイクロバブルが存在しないことや,タイプIのマイクロバブルが存在することは,過剰な組織加熱を排除するものではありませんでした.
結論:
- カテーテル先と組織の間には,冷やした先の切除の際に顕著な温度差異が存在する.
- 微小泡の形成は,潜在的な組織過熱の指標であり,エネルギー供給の減少を保証します.
- 現在のモニタリング方法では,アブレーション中に過度の組織加熱のリスクが完全に捉えられない可能性があります.
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