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Updated: Jul 16, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

溶性エポキシードヒドロラーゼにおけるフォスファタゼ活性に関する計算による研究:水橋媒介型陽子シャトルによる高効率

Marco De Vivo1, Bernd Ensing, Michael L Klein

  • 1Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA. mdevivo@cmm.upenn.edu

Journal of the American Chemical Society
|August 11, 2005
PubMed
まとめ

溶解性エポキシードヒドロラーゼ (sEH) は,新種のフォスファターゼ活性を示し,薬の開発のための新しい標的を明らかにしています. 計算による研究は,触媒作用に不可欠な水橋を含む協調反応機構を明らかにした.

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