アンジオテンシン変換酵素の挿入/削除遺伝子型,運動,そして身体的衰退
Stephen B Kritchevsky1, Barbara J Nicklas, Marjolein Visser
1The Sticht Center on Aging and Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. skritche@wfubmc.edu
JAMA
|August 11, 2005
まとめ
身体活動は,高齢者の運動制限を軽減します. しかし,アニオテンシン変換酵素 (ACE) 遺伝子型がこの利点に影響を与え,II遺伝子型は活発な個体の中でリスクが増加しています.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 遺伝学 遺伝学とは
- 運動生理学 運動生理学
背景:
- アンジオテンシン変換酵素 (ACE) 挿入 (I) /消去 (D) ゲノタイプは,若年成人の身体能力と関連しています.
- 高齢者の運動反応と運動制限におけるその役割は,まだ十分に研究されていない.
研究 の 目的:
- 機能の良い高齢者の運動制限の予測におけるACE遺伝子型と身体活動の相互作用を調査する.
主な方法:
- Health Aging and Body Composition (Health ABC) 研究では,70歳から79歳までの3075人の成人を対象に実施した.
- 移動能力の制限は,0.4km歩行または10段の階段を登る困難として定義されました.
- 追跡期間は平均4.1年でした.
主要な成果:
- 身体活動 (>1000 kcal/wk) は,ACE遺伝子型に関係なく,運動制限のリスクを軽減します.
- ACE遺伝子型と身体活動の間の有意な相互作用が観察されました (P = .002).
- 活発な参加者の中で,ACE II遺伝子型は,ID/DD遺伝子型と比較して,特にウェイトリフティングと比べて,移動能力の制限のリスクが高い (調整率比1.45) と関連していました.
結論:
- 運動したACEDDまたはID遺伝子型を持つ高齢者は,II遺伝子型の人よりも,運動制限のリスクが低い.
- 運動は,すべてのACE遺伝子型において,一貫して運動能力制限のリスクを軽減します.
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