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Updated: May 5, 2026

Lentiviral Mediated Gene Silencing in Human Pseudoislet Prepared in Low Attachment Plates
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ARNT/HIF1βの損失は,ヒトの2型糖尿病における遺伝子発現の変化と臓島機能障害を媒介する

Jenny E Gunton1, Rohit N Kulkarni, SunHee Yim

  • 1Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA.

Cell
|August 13, 2005
PubMed
まとめ

転写因子ARNTのレベル低下は,グルコース刺激によるインスリン放出を阻害し,2型糖尿病におけるβ細胞機能障害に貢献します. この発見は,ARNTを強調しています.

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