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Updated: Jul 17, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
ロフルミラスト - 慢性閉塞性肺疾患の口服抗炎症療法:ランダム化制御試験
Klaus F Rabe1, Eric D Bateman, Denis O'Donnell
1Leiden University Medical Centre, Leiden, Netherlands. k.f.rabe@lumc.nl
Lancet (London, England)
|August 16, 2005
まとめ
ロフルミラストは,慢性閉塞性肺疾患 (COPD) の患者の肺機能を改善し,悪化を軽減しました. 生活の質への長期的な影響を確認するためにさらなる研究が必要です.
科学分野:
- 肺内科 肺内科 肺内科
- 薬理学 薬理学とは
- クリニック・トライアル 臨床試験
背景:
- 慢性阻害性肺疾患 (COPD) は,進行的な気流制限と慢性炎症を伴うもので,治療の選択肢は限られている.
- フォスフォディエステラゼ-4阻害剤であるロフルミラストは,中度重症から重症のCOPD患者の有効性と安全性について調査されました.
研究 の 目的:
- 中度重症から重症のCOPDの治療におけるロフルミラストの有効性と安全性を評価する.
- ロフルミラストが肺機能,生活の質,悪化に与える影響を評価する.
主な方法:
- ステージIII,マルチセンター,ダブルブラインド,ランダム化,プラセボ対照試験.
- 1411人のCOPD患者は,24週間にわたり,経口でロフルミラスト (250または500マイクログラム) またはプラセボを1日1回投与された.
- プライマリアウトカムには,支氣管拡張後のFEV1と健康関連の生活の質が含まれ,二次的なアウトカムには,肺機能と悪化が含まれていました.
主要な成果:
- 両方のロフルミラストの投与量は,プラセボと比較して,ブロンコディレーター後のFEV1を有意に改善しました (p<0.0001).
- ロフルミラストは,統計的に有意ではないが,生活の質を改善する傾向を示した.
- プラセボと比較して,ロフルミラストを投与した患者あたりの平均悪化は減少した.
結論:
- ロフルミラストは,COPDの抗炎症療法として,肺機能を改善し,悪化を軽減する可能性を示しています.
- ロフルミラストの健康関連の生活の質への影響を完全に評価するために,長期の研究が推奨されます.
関連する概念動画
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:24Antiasthma Drugs: Methylxanthines
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...