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Updated: Jul 17, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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CheAヒスティジンキナーゼの自己リン酸化のためのダイナミックメカニズム:分子ダイナミクスシミュレーション

Jian Zhang1, Yechun Xu, Jianhua Shen

  • 1Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.

Journal of the American Chemical Society
|August 18, 2005
PubMed
まとめ

この研究は,ATPが細菌の2組分システム (TCS) で,フォスフォリルドナーとアクティベーターとしてどのように作用するかを明らかにしています. ATP結合はP4ドメインの構造変化を引き起こし,P1結合とそれ以降の自己リン酸化のための蓋を開く.

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