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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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ポリプロリンヘリックス・スキャフォールドに基づく細胞浸透剤.

Yannick A Fillon1, Jason P Anderson, Jean Chmielewski

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA.

Journal of the American Chemical Society
|August 18, 2005
PubMed
まとめ

ポリプロリンヘリックス構造に基づく新しい細胞浸透剤は,細胞の吸収を大幅に強化しています. これらのアンフィフィリック剤,特にグアニジニウム基を持つものは,柔軟なペプチドとタットペプチドを最小限の毒性で上回ります.

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