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Updated: May 2, 2026

2 in 1: One-step Affinity Purification for the Parallel Analysis of Protein-Protein and Protein-Metabolite Complexes
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エクソトキシンA-eEF2複合体の構造は,リボソーム模倣によるADPリボシレーションを示しています

René Jørgensen1, A Rod Merrill, Susan P Yates

  • 1Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000, Denmark.

Nature
|August 19, 2005
PubMed
まとめ

Pseudomonas aeruginosa exotoxin A (ETA) のような細菌の毒素は,ADPリボシレーションを用いてタンパク質を修正する. 延長因子2 (eEF2) のディフタミド残基は,この反応に不可欠であり,毒素とNAD+と相互作用する.

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