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Updated: Jul 17, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

グルタレドキシン5の欠乏は,脊椎動物のヘム合成のためにFe-Sクラスターが必要であることを明らかにする

Rebecca A Wingert1, Jenna L Galloway, Bruce Barut

  • 1Stem Cell Program and Division Hematology/Oncology Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 20, 2005
PubMed
まとめ

鉄硫黄 (Fe-S) クラスター組成は,ヘモグロビン生産に不可欠です. この研究では,ゼブラフィッシュのFe-Sクラスター組成の障害が,鉄調節タンパク質1 (IRP1) を活性化させ,ヘム生物合成を阻害することを明らかにしました.

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