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Updated: May 12, 2026

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Implantation of the Syncardia Total Artificial Heart
Published on: July 18, 2014
心臓サポート装置は,心筋梗塞の後に左心室の幾何学と心筋の構造を変更します
Aaron S Blom1, Rupak Mukherjee, James J Pilla
1Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Circulation
|September 1, 2005
まとめ
心臓サポート装置 (CSD) は,心筋梗塞 (MI) の後の左心室 (LV) の不良改造を減少させた. この機械的抑制は,筋細胞の機能を改善し,細胞の反応を正常化し,MI後の回復に非薬理学的アプローチを提供しました.
科学分野:
- 心血管科学の研究について
- バイオメディカルエンジニアリング
- 再生医学は,再生医療である.
背景:
- 機械的な左心室 (LV) 抑制が心筋梗塞 (MI) の後の再構築に与える影響は十分に理解されていません.
- 本研究では,心筋梗塞の後に心筋梗塞支援装置 (CSD) がLVおよび肌細胞の幾何学および機能に及ぼす影響を調査しています.
研究 の 目的:
- 心筋梗塞 (MI) の後の左心室 (LV) の不良改造を緩和する心臓サポート装置 (CSD) の有効性を評価する.
- 機械的なLVサポートが,心筋梗塞後の心筋再構築に影響を与える細胞および細胞外メカニズムを調査する.
主な方法:
- 誘発性心筋梗塞 (MI) を患った羊のモデルは,心臓サポート装置 (CSD) を受けたり,未治療のコントロールとして使用するためにランダムに割り当てられました.
- 心臓磁気共鳴画像 (MRI) は,LVの量を評価し,隔離された筋細胞機能,β-アドレナジック応答,およびコラーゲン含有量はMIの3ヶ月後に分析されました.
主要な成果:
- CSDグループは,MIのみのグループと比較して,LVの末期透析容量の減少を示したが,それはコントロール群よりも高いままでした.
- 筋細胞の縮小速度は,両方のMIグループで減少したが,ベータアドレナジック反応は,CSDグループで正常化した.
- LVミオサイトの長さは減少し,CSDグループではコラーゲン含有量が増加し,MIの境界地帯ではマトリックスメタルプロテインアゼ-9が減少した.
結論:
- 心臓のサポート装置 (CSD) は,心筋梗塞後のLVと筋細胞再構成を有益に修正しました.
- CSDは,細胞および細胞外メカニズムの両方を通じて有効性を実証しました.
- これらの発見は,心筋梗塞後の不良のLVリモジレーションを中断するための非薬理学的戦略を支持します.
関連する概念動画
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Location and Orientation of the Heart
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

