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関連する概念動画

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.9K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

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分子時計は,レプチン調節による骨形成を媒介する.

Loning Fu1, Millan S Patel, Allan Bradley

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030; Bone Disease Program of Texas, Baylor College of Medicine, Houston, Texas 77030, USA.

Cell
|September 7, 2005
PubMed
まとめ

レプチンと分子時計は,骨の形成を調節する. 時計遺伝子は,共感的なシグナル伝達を媒介する.

科学分野:

  • エンドクリノロジー エンドクリノロジー
  • クロノバイオロジー クロノバイオロジー
  • 骨の生物学 骨の生物学

背景:

  • レプチンは,骨の再建と骨質の重要な調節因子です.
  • シルカディアンクロック遺伝子 (PerとCry) は骨質に影響を与え,欠乏すると高骨質になる.
  • ペル素欠乏症のマウスは,レプチン注入後,骨質が増加し,レプチン媒介の骨調節における時計遺伝子の役割を示唆しています.

研究 の 目的:

  • レプチンによる骨形成の共感神経系の調節を媒介する分子時計遺伝子の役割を調査する.
  • レプチンがシンパティックシグナル伝達と時計遺伝子を介して,オステオブラストの増殖と骨質に影響を与えるメカニズムを解明する.

主な方法:

  • 交感神経系とレプチンの影響下でオステオブラストのクロック遺伝子発現の分析.
  • G1サイクリン発現とオステオブラスト増殖に対する時計遺伝子の影響の評価.
  • レプチンのAP-1遺伝子発現への影響と,サイクリンD1のアップレギュレーションにおけるその役割の評価.

主要な成果:

  • 交感神経系とレプチンは,オステオブラストの時計遺伝子発現を調節する.
  • 時計遺伝子は,G1サイクリン発現を抑制することによって,オステオブラストの増殖を抑制します.
キーワード:
非プログラム的なものです.

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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

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関連する実験動画

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation
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  • レプチンは,AP-1を上調することで,この阻害に対抗し,サイクリンD1発現,骨質芽細胞増殖,骨形成を促進します.

    • 結論:

    • レプチンは,共感信号伝達と分子時計を含む二重,敵対的な経路を通じて,骨質細胞の増殖と骨形成を調節する.
    • 分子時計は,骨の再編成の同情的調節を媒介する上で重要な役割を果たします.
    • これらの経路を理解することで,骨の恒常性および潜在的な治療目標の維持に関する洞察が得られます.