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Updated: Aug 17, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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ラパミシンは,p70 S6キナーゼのインターリューキン-2活性化を選択的に抑制する

C J Kuo1, J Chung, D F Fiorentino

  • 1Howard Hughes Medical Institute, Unit in Molecular and Genetic Medicine, Beckman Center, Stanford University School of Medicine, California 94305-5425.

Nature
|July 2, 1992
PubMed
まとめ

マクロリドラパミシンは,p70 S6キナーゼの活性化を阻害することによって,細胞サイクル進行を停止します. この発見は,T細胞の増殖と免疫抑制を調節する保存された経路を明らかにしています.

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