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Updated: Jul 15, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

PUMAは,p53の核と細胞プラズマのプロアポプトティック機能を組み合わせる

Jerry E Chipuk1, Lisa Bouchier-Hayes, Tomomi Kuwana

  • 1Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

Science (New York, N.Y.)
|September 10, 2005
PubMed
まとめ

腫瘍抑制剤Trp53 (p53) は,アポトーシスにおける核と細胞質の役割が異なっている. Bcl-xL,p53,およびPUMAの相互作用がこれらの機能を調整し,PUMAはアポトーシスの開始に不可欠です.

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